NCT lookup
Pull any trial record directly from ClinicalTrials.gov.
Sponsor: University of Washington
Conditions: Tuberculosis, HIV I Infection
Interventions: Community-delivered TB preventive therapy (TPT) - 3 months weekly isoniazid plus rifapentine (3HP), Clinic-link TPT
Countries: South Africa
This study will compare community-delivered, multi-month dispensing of tuberculosis preventive therapy (TPT) to standard-of-care clinic-based TPT delivery in a population of South African adults who are recommended to receive TB preventive therapy. We hypothesize that persons receiving multi-month dispensing of TPT in the community will have a higher rate of TPT completion at 3 months than persons receiving TPT via standard of care with monthly clinic-based refills.
Sex: ALL
Age: 18 Years to —
Healthy volunteers: No
Study type: INTERVENTIONAL
Inclusion Criteria: * ≥18 years of age * Living in the study catchment area * Eligible for TPT according to South African National guidelines(5), i.e. are a) living with HIV or b) are a close contact of a person with TB disease (defined by a person that resides in the same house as a person with TB), c) and in either case * Have screened negative for TB disease in the last 6 months, through TB TRIAGE+ Trial, other household contact tracing, or other community TB screening * Negative TB screening at enrolment (if TB TRIAGE+ screening was more than 3 months ago) * Willing and able to provide written or verbal consent * Participants whom have not received TPT in the last 12 months; this was confirmed verbally with participants during the enrolment process. Exclusion Criteria: * Less than 18 years of age. * Pregnant or planning on pregnancy within next three months * Planning on moving or relocating from the area within the next three months * Positive for active TB * Currently on TB treatment
- Sweetwaters, KwaZulu-Natal, South Africa