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A Longitudinal Multi-Omic Biomarker Profiling Study of Patients With Head & Neck Squamous Cell Carcinoma (HNSCC)

RecruitingN/A

Sponsor: Tempus AI

Conditions: Head and Neck Squamous Cell Carcinoma

Countries: United States, Puerto Rico

The study is a prospective, longitudinal, non-interventional, multicenter study of participants with HNSCC who will have tissue and blood based molecular biomarker profiling during their standard of care treatment.

Eligibility overview

Sex: ALL

Age: 18 Years to —

Healthy volunteers: No

Study type: OBSERVATIONAL

Eligibility criteria

Inclusion Criteria:

* ≥18 years of age
* Willing and able to provide informed consent
* Histologically- or cytologically-confirmed metastatic or unresectable, recurrent HNSCC unsuitable for local therapies
* Intended for first line anti-PD1 or PDL1 monotherapy or combination therapy
* Must submit tumor tissue sample representative of current disease per laboratory manual

Exclusion Criteria:

* Non-squamous histologies (eg, nasopharynx or salivary gland)
* Relapse or recurrence within 6 months of first line chemotherapy and / or chemoradiotherapy
* Tumors that are PD-L1 negative (CPS \<1)
* Clinical evidence of an active second invasive malignancy within \<2 years of enrollment with the exception of stable prostate cancer on watchful waiting, in situ cervical cancer, in situ breast carcinoma or localized non-melanoma skin cancers
* Unable to comply with study procedures (i.e., not willing or able to have additional blood samples collected)

Locations (30)

Duarte, California, United States
Los Angeles, California, United States
Los Angeles, California, United States
Palo Alto, California, United States
Santa Rosa, California, United States
Atlanta, Georgia, United States
Atlanta, Georgia, United States
Atlanta, Georgia, United States
Chicago, Illinois, United States
Decatur, Illinois, United States
Peoria, Illinois, United States
Westwood, Kansas, United States
Baltimore, Maryland, United States
Boston, Massachusetts, United States
Detriot, Michigan, United States
Detroit, Michigan, United States
Springfield, Missouri, United States
St Louis, Missouri, United States
New York, New York, United States
Fargo, North Dakota, United States
Cincinnati, Ohio, United States
Cleveland, Ohio, United States
Columbus, Ohio, United States
Philadelphia, Pennsylvania, United States
York, Pennsylvania, United States
Sioux Falls, South Dakota, United States
Nashville, Tennessee, United States
Seattle, Washington, United States
Appleton, Wisconsin, United States
San Juan, Puerto Rico