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Study of Inflammatory and Physiological Profiles of Healthy and Diseased Lung

RecruitingN/A

Sponsor: Guy's and St Thomas' NHS Foundation Trust

Conditions: COPD, Asthma, Airway Disease

Countries: United Kingdom

There are over 700,000 UK hospital admissions every year with lung disease symptoms. Two of the most common lung diseases contributing to these numbers are asthma and chronic obstructive pulmonary disease (COPD). The immunopathology of these diseases is not fully understood. Matched samples from the respiratory tract and circulation will be used to identify immune patterns throughout the respiratory system to elucidate the immunopathology of airway disease.

Eligibility overview

Sex: ALL

Age: 18 Years to —

Healthy volunteers: Yes

Study type: OBSERVATIONAL

Eligibility criteria

Inclusion Criteria:

* Participant is willing and able to give informed consent for participation in the study
* Aged 18 years or above
* Patient: known or suspected airway disease
* Healthy volunteer: considered to be in good health with no significant comorbidity (immune disorder, cancer etc.)

Exclusion Criteria:

* Known or suspected current pulmonary tuberculosis, HIV (human immunodeficiency virus), Hepatitis B Virus, Hepatitis C Virus.
* Surgery within the preceding 6 weeks
* Participants who are pregnant
* History of psychiatric, medical, or surgical disorders that in the opinion of the chief investigator may interfere with sample collection, undergo a bronchoscopy, or may compromise study completion or data collection
* Alcohol or recreational drug abuse
* Diagnosis of immunodeficiency requiring treatment
* Unable to provide written informed consent
* Unable to read or write English
* Be considered, in the opinion of the investigator, to be an unsuitable candidate for the study

Locations (1)

London, London, United Kingdom