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Study to Evaluate Safety, Tolerability and Drug Levels of BMS-986435/MYK-224 in Participants With Heart Failure With Preserved Ejection Fraction (HFpEF)

NCT06122779

Active Not RecruitingPhase 2

Sponsor: Bristol-Myers Squibb

Conditions: Heart Failure

Interventions: BMS-986435, Placebo

Countries: United States, Argentina, Canada, China, Israel, Italy, Japan, Poland

The purpose of this study is to evaluate the safety, tolerability, and exposure-response (E-R) of BMS-986435/MYK-224 in participants with symptomatic Heart Failure with Preserved Ejection Fraction (HFpEF).

Eligibility overview

Sex: ALL

Age: 40 Years to 85 Years

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria

\- Adult participants with stable, symptomatic HFpEF with a normal heart pumping ability.

Exclusion Criteria

* Participants must not have a known diagnosis of obstructive or genetic hypertrophic cardiomyopathy or infiltrative/storage disorder such as cardiac amyloidosis, or any other acute or serious condition that could interfere with assessments during the study or may pose a risk to the participant.
* Other protocol-defined Inclusion/Exclusion criteria apply.

Locations (86)

Birmingham, Alabama, United States
Lakewood, Colorado, United States
Jacksonville, Florida, United States
Miami, Florida, United States
Miami, Florida, United States
Chicago, Illinois, United States
Hazel Crest, Illinois, United States
Indianapolis, Indiana, United States
St Louis, Missouri, United States
Hackensack, New Jersey, United States
Albany, New York, United States
Brooklyn, New York, United States
New York, New York, United States
Rochester, New York, United States
Rochester, New York, United States
Rosedale, New York, United States
Durham, North Carolina, United States
Oklahoma City, Oklahoma, United States
Abington, Pennsylvania, United States
Tullahoma, Tennessee, United States
Austin, Texas, United States
Dallas, Texas, United States
Houston, Texas, United States
Ciudad del Libertador General San Martin, Buenos Aires, Argentina
Zárate, Buenos Aires, Argentina
Córdoba, Córdoba Province, Argentina
Córdoba, Córdoba Province, Argentina
Rosario, Santa Fe Province, Argentina
San Miguel de Tucumán, Tucumán Province, Argentina
Buenos Aires, Argentina
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