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Biomarkers in Patients With Suspected HFpEF

RecruitingN/A

Sponsor: NHS Greater Glasgow and Clyde

Conditions: Heart Failure, Obesity, Heart Failure With Preserved Ejection Fraction

Interventions: Plasma biomarker levels

Countries: United Kingdom

NT-proBNP does not adequately identify HF(pEF) in people with suspected HF at low levels, particularly in patients with obesity. This study will investigate: 1. alternative cut-offs for NT-proBNP to identify HF(pEF) in people with suspected HF and obesity 2. novel candidate biomarkers to identify HF(pEF) in people with suspected HF and obesity. 3. novel candidate biomarkers to identify HF(pEF) in people with suspected HF and NT-proBNP \<125 ng/L 4. the prevalence of HF in people with suspected HF and low NT-proBNP \<125 ng/L)

Eligibility overview

Sex: ALL

Age: 18 Years to —

Healthy volunteers: No

Study type: OBSERVATIONAL

Eligibility criteria

Inclusion Criteria:

* Written informed consent
* Age ≥ 18 years
* NT-proBNP sample taken by primary care physician as part of routine care for suspected heart failure

Exclusion Criteria:

* Unable to consent to inclusion in study due to significant cognitive impairment
* Geographical/ social reasons preventing attending study centre
* Unable to complete study assessments
* Patients presenting with acute HF or a previous diagnosis of HF

Locations (3)

Glasgow, United Kingdom
Glasgow, United Kingdom
Glasgow, United Kingdom