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Uptake of the Childhood Live Attenuated Influenza Vaccine (LAIV) and Influenza-related Healthcare Resource Use in England During the 2012 to 2022 Flu Seasons; a Retrospective, Observational Study in the CPRD and HES Databases

NCT06077045

CompletedN/A

Sponsor: AstraZeneca

Conditions: Influenza

Countries: United Kingdom

In 2013, the NHS started a vaccination program in some regions of England to provide free flu vaccines to children aged 2 years or older, and younger than 16 years. The program has since been rolled out across England. Most children are given a vaccine that is sprayed into their nose. In clinical trials, this vaccine has been shown to protect children from experiencing severe flu symptoms. It is important to describe how it is used, and what happens to children who receive it in the wider community. This evidence will help the NHS to check that the vaccine roll out runs as planned and produces the intended benefits. This study aims to: (1) describe how many children each year receive flu vaccines, and describe the characteristics of children who are and aren't vaccinated for influenza; (2) test how often children receiving the vaccine see their GP or a hospital doctor for symptoms related to flu, compared to those who don't; and (3) to test what groups of children are more or less likely to receive a flu vaccine. To answer these objectives, the study will use the Clinical Practice Research Datalink, linked to Hospital Episode Statistics and the Office for National Statistics database.

Eligibility overview

Sex: ALL

Age: 0 Years to 17 Years

Healthy volunteers: No

Study type: OBSERVATIONAL

Eligibility criteria

The reference study cohort will include patients as follows:

* Aged ≥2 and \<18 years at any time between 1 September 2012 and 30 April 2020
* Classified as eligible for inclusion in research analysis according to CPRD guidance

In each flu season, the following criteria apply:

Inclusion Criteria:

* Aged ≥6 months and \<2 years on the 1st September
* Have a high-risk condition as listed in the Green Book.

Exclusion Criteria:

* Were deceased or had migrated out of their practice prior to the 1st September in the current influenza season.
* Were recorded has receiving both QIV and LAIV in the current influenza season.

Locations (1)

London, United Kingdom