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A Study of Eltrekibart (LY3041658) in Adult Participants With Moderate to Severe Hidradenitis Suppurativa

CompletedPhase 2

Sponsor: Eli Lilly and Company

Conditions: Hidradenitis Suppurativa

Interventions: Eltrekibart, Placebo

Countries: United States, Australia, Canada, Germany, Greece, Poland

This study aims to find the appropriately safe and effective dose and dosing frequency for eltrekibart in adults with moderate-to-severe hidradenitis suppurativa (HS) for further clinical development. The study will last approximately 62 weeks and may include up to 31 visits.

Eligibility overview

Sex: ALL

Age: 18 Years to 75 Years

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* Have a diagnosis of HS for at least 12 months.
* Have HS lesions in at least 2 distinct anatomical regions. At least 1 of the lesions must be at least Hurley Stage II or III.
* Have an (abscess plus inflammatory nodule) count of at least 5.
* Agree to use topical antiseptics daily.
* Had an inadequate response or intolerance to a 28-day course of oral antibiotics.

Exclusion Criteria:

* Have more than 20 draining fistulae.
* Have had surgical treatment for HS in the last 4 weeks before randomization.
* Have an active skin disease or condition, that could interfere with the assessment of HS.
* Have a current or recent acute, active infection.
* Are immunocompromised.
* Have a history of chronic alcohol abuse, IV drug abuse, or other illicit drug abuse within 1 year before screening.

Locations (74)

Phoenix, Arizona, United States
Phoenix, Arizona, United States
North Little Rock, Arkansas, United States
Rogers, Arkansas, United States
Fountain Valley, California, United States
Fremont, California, United States
Los Angeles, California, United States
Santa Monica, California, United States
Farmington, Connecticut, United States
Hialeah, Florida, United States
Miami, Florida, United States
Miami, Florida, United States
Tampa, Florida, United States
Tampa, Florida, United States
Tampa, Florida, United States
Sandy Springs, Georgia, United States
Skokie, Illinois, United States
Indianapolis, Indiana, United States
Bowling Green, Kentucky, United States
Louisville, Kentucky, United States
Marriottsville, Maryland, United States
Boston, Massachusetts, United States
Troy, Michigan, United States
St Louis, Missouri, United States
Omaha, Nebraska, United States
Portsmouth, New Hampshire, United States
Charlotte, North Carolina, United States
Charlotte, North Carolina, United States
Durham, North Carolina, United States
Cleveland, Ohio, United States
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