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Virologic and Immunologic Characteristics of Severe Mpox in Persons With Advanced HIV

TerminatedN/A

Sponsor: Centers for Disease Control and Prevention

Conditions: Monkeypox, HIV Infections, AIDS

Countries: United States

The purpose of this study is to examine the extent of mpox viral spread and immunologic markers in people with advanced HIV. Study findings will enhance knowledge of mpox pathogenesis in severely immunocompromised people, which can inform treatment and prevention of severe illness and deaths associated with mpox in people with advanced HIV.

Eligibility overview

Sex: ALL

Age: 18 Years to —

Healthy volunteers: No

Study type: OBSERVATIONAL

Eligibility criteria

Inclusion Criteria:

* Age ≥18 years; AND
* HIV infection with CD4 count \< 200 cells/uL; AND
* Probable or confirmed mpox (does NOT need to be a new diagnosis); AND
* Hospitalized while symptomatic from mpox, for reasons other than (or in addition to) infection prevention and control

Exclusion Criteria:

* Inability of the individual or appropriate proxy to provide informed consent.
* In the judgment of the clinical treating team, has a medical condition or other factor that might affect their ability to participate in the evaluation.

Locations (1)

Atlanta, Georgia, United States