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Sponsor: University of North Carolina, Chapel Hill
Conditions: Stress, Psychological, Motivation
Interventions: Minocycline, Placebo
Countries: United States
Motivational deficits such as anhedonia are core to several psychiatric disorders and underlie significant functional impairment. This double-blind, placebo-controlled crossover trial of minocycline, an anti-\[neuro\]inflammatory agent, examines links between chronic stress and responses to a reward-related motivation task. It will evaluate the effects of pharmacologically attenuating neuroinflammation on behavioral responses to a reward-related motivation task in individuals experiencing unemployment. Understanding the effects of neuroinflammation on reward function among individuals experiencing chronic stress represents a critical first step in identifying novel neuroimmune targets for future clinical trials.
Sex: ALL
Age: 25 Years to 60 Years
Healthy volunteers: Yes
Study type: INTERVENTIONAL
Inclusion Criteria: * 25-60 years old * Unemployed (working less than 20 hours per week) * Have been unemployed for at least 6 months * Seeking employment * Having trouble finding a job (i.e., actively seeking and applying for jobs but not successful in landing a job) * Reports greater than 5 points on Job Stress Items * Regular access to a mobile phone Exclusion Criteria: * Self-reported physical illnesses: diabetes, cardiovascular diseases, high blood pressure, inflammatory bowel diseases, rheumatoid arthritis, asthma, autoimmune disease, Crohn's disease, ulcerative colitis, lupus * neurological conditions (e.g., Traumatic Brain Injury, stroke) * pregnant (as measured by urine pregnancy screen) or breastfeeding * current use of psychotropic medications * Current regular recreational drug or alcohol use (i.e., 4 or more times per week) * chronic diseases that significantly impact inflammatory markers (e.g., cancer) * known allergies or hypersensitivities to tetracycline antibiotics, aspirin or other NSAIDs * current antibiotic use * regular use of steroidal or non-steroidal anti-inflammatory medications (i.e., 2 or more times a week)
- Chapel Hill, North Carolina, United States