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Assessing the Role of Mitochondrial Dysfunction in Primary Progressive Multiple Sclerosis
Assessing the Role of Mitochondrial Dysfunction in Primary Progressive Multiple Sclerosis

NCT06025903

UnknownN/A

Sponsor: IRCCS San Raffaele

Conditions: Multiple Sclerosis

Countries: Italy

The purpose of this project is to study genetic determinants of mitochondrial impairment in primary progressive multiple sclerosis. Specific aims are: 1) identify mitochondrial-related pathways, inherited and somatic mitochondrial DNA mutations associated to primary progressive multiple sclerosis, 2) functionally assess the identified genetic alterations.

Eligibility overview

Sex: ALL

Age: 18 Years to —

Healthy volunteers: No

Study type: OBSERVATIONAL

Eligibility criteria
Inclusion Criteria:

* Patients affected by primary progressive or relapsing remitting multiple sclerosis
* Patient able to provide informed consent

Exclusion Criteria:

* Individuals with \< 18 years
* Patients not affected by primary progressive or relapsing remitting multiple sclerosis
Locations (2)
  • Milan, MI, Italy
  • Gallarate, VA, Italy