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Reversibility of Methacholine Induced Bronchoconstriction

CompletedPhase 4

Sponsor: University of Saskatchewan

Conditions: Asthma

Interventions: salbutamol aqueous solution, salbutamol pressurized metered dose inhaler, placebo

Countries: Canada

The study will compare salbutamol reversibility of methacholine induced bronchoconstriction between a pressurized metered dose inhaler with a spacer versus nebulizer administration using a vibrating mesh nebulizer.

Eligibility overview

Sex: ALL

Age: 18 Years to —

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* age (years) at least 18, male or female
* no confounding health issue (i.e. no health conditions, other than asthma, that would put the participant at risk or affect data integrity)
* baseline FEV1 ≥ 65% predicted (per Quanjer GLI 2012)
* methacholine PD20 ≤ 800mcg

Exclusion Criteria:

* respiratory infection within 4 weeks of Visit 1
* exposure to triggers of respiratory symptoms within 4 weeks of Visit 1
* currently pregnant or breastfeeding
* current smoker (cigarettes, vaping)

Locations (1)

Saskatoon, Saskatchewan, Canada