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Patients are included into the study if they meet the following criteria :

1. Adults aged 40 years and above as of the index hospitalization admission date (for the intervention arm only).
2. Primary or secondary diagnosis of COPD as documented in the database on or before admission.
3. Hospital admission for a COPD exacerbation (primary or secondary cause) (ie, the index admission).
4. Availability of at least 6 months of data in the PHD-LRx-Dx database prior to the index admission (for the comparator arm only).
5. Additional inclusion criteria for the interventional arm:

   1. Willingness to use Breztri as an inhaled maintenance medication as prescribed by their physician.
   2. Willingness and ability to sign informed consent during index admission and before discharge.
   3. Availability of home-based access to telephone calls.
   4. Availability of home-based access to the internet for PRO measurement and inhaler training materials.
   5. Willingness to be contacted by a qualified medical professional for safety monitoring.
   6. Willingness and ability to participate, on their own or through the assistance of their caregivers, in remote, online patient-reported outcome measurement at designated intervals
   7. Physician decision that patient is eligible for treatment with Breztri according to the approved USPI.
   8. Any females of childbearing potential must be using a form of highly effective methods of contraception and have a negative urine pregnancy test result
6. Additional inclusion criterion for the comparator arm:

   1. Received non-triple inhaled therapy for COPD within 30 days prior to discharge or up to 30 days post-discharge, including:

      * ICS/LABA.
      * LABA/LAMA.
      * ICS.
      * LABA.
      * LAMA.
      * SABA/SAMA.
      * SABA.
      * SAMA.
      * Other inhaled COPD therapy not classified as triple therapy.

Exclusion Criteria:

Patients are excluded from the study if they meet any of the following criteria:

1. Having received triple inhaled maintenance therapy (fixed-dose, or open) for COPD or other indications 6 months prior to index admission.
2. Any documented use of respiratory biologics 6 months prior to index admission.
3. Patients on palliative care, including hospice.
4. Discharge to institutional care other than a rehabilitation facility (eg, other hospital, or similar). Patients discharged to rehabilitation facility are eligible to participate. Note: Because patients are enrolled in the intervention arm prior to discharge, this criterion should be assessed using the working knowledge of the treating physician at the time of patient enrollment.
5. Mortality on or before index discharge.
6. Conditions including lung surgery (excluding thoracentesis or chest tube insertion or thoracostomy) in 6 months prior to index admission, history of pulmonary lobectomy, cystic fibrosis, interstitial lung disease, lung cancer, or alpha-1 antitrypsin deficiency (A1ATD) inducing severe disease as recorded in the PHD-LRx-Dx database.
7. For females only - currently pregnant (confirmed with positive pregnancy test) or breast-feeding or planning to become pregnant in the year following index discharge.
8. Additional exclusion criteria for the interventional arm:

   1. Discharged on a triple inhaled maintenance therapy in addition to Breztri.
   2. Patients who have a history of hypersensitivity to β2-agonists, budesonide or any other corticosteroid components, glycopyrronium or other muscarinicanticholinergics, or any component of the MDI.
   3. Patients who are clinically unstable, ie, still admitted within the intensive care unit,with ongoing dyspnea, requiring vasopressors or round-the-clock positive airway pressure ventilatory support.