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Sponsor: Wageningen University
Conditions: Aging
Countries: Netherlands
Aging is commonly associated with reduced functionality of the immune system, resulting in a higher prevalence of infectious disease, auto-immune disease, cancer, and lower efficiency of vaccination. Nutritional strategies are increasingly recognized as a method to improve immune functionality, as several nutrients are shown to exert immunomodulatory properties. However, the large variation between individuals with regard to immune responses asks for more personalized approaches. Therefore, this field of research would benefit from a selection of those individuals with immune dysfunction. It is recently shown that immune functionality is largely dependent on intracellular metabolism, leading to the introduction of the new term 'immune cell fitness' which combines the metabolic and functional status of an immune cell. Within this study, we will determine the immune cell fitness of monocytes from healthy young adults and elderly subjects by measuring and integrating a broad range of metabolic and functional immune parameters into an immune cell fitness score. We aim to identify those individuals with immune dysfunction, the unfit. Furthermore, to identify potential nutritional strategies to improve immune cell fitness, we will study the effects of metabolites and nutrients on the immune cell fitness status of monocytes from elderly subjects.
Sex: ALL
Age: 20 Years to 75 Years
Study type: OBSERVATIONAL
Inclusion Criteria: * Age 20 - 30y and 60 - 75y * BMI 18.5 - 25 kg/m2 (young adults); 20 - 30 kg/m2 (elderly) * Willing to fast overnight for 12 hours * Willing to give a blood sample * Having a general practitioner * Signed informed consent Exclusion Criteria: * Diagnosed with metabolic and/or inflammatory disease (e.g. diabetes, cardiovascular disease (with the exception of hypertension), arthritis, arthrosis, glycogen storage dis-orders and auto-immune diseases) * Current diagnosis of cancer * Regular use of medication that interferes with immune function (e.g. corticosteroids, cytokine blockers) * Regular use of medication that may interfere with metabolism (e.g. metabolic inhibitors or activators) * Use of medication that interferes with immune function and metabolism in at least one week preceding the study visit (e.g. NSAID, anti-histamines, corticosteroids) * More than 4kg weight gain or weight loss over the last 4 months * Vaccination within 3 months preceding the study visit (e.g. immunization against influ-enza, pneumonia, and travel-related infections) * Donated blood within 2 months preceding the study visit * Pregnant, lactating or wishing to become pregnant in the period between the screening and study visit (self-reported) * Regular use of hard drugs and soft drugs (i.e. weekly use) and at least no use within 2 months preceding the study visit * Excessive alcohol use (i.e. \>14 units per week) * Use of cigarettes and other tobacco products * Participation in another study that involves an intervention 2 months preceding the study visit * Members of the research team * Working, or doing an internship or thesis at the division "Human Nutrition and Health", Wageningen University
- Wageningen, Gelderland, Netherlands