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Sponsor: University of Nottingham
Conditions: Aging, Sarcopenia
Interventions: High intensity interval training (HIIT), Resistance based training (RET)
Countries: United Kingdom
The goal of this interventional study is to learn about the role of mitochondrial function in healthy aging, and then go on and assess the role of a home-based exercise program on the changes seen. The main question\[s\] it aims to answer are: * What alterations in skeletal muscle mitochondrial function are seen in healthy aging? * Can a short-term exercise program alter these alterations seen? The older participants will be invited to take part in a home-based 4 week exercise intervention involving either: * High intensity interval training * Resistance based training (resistance bands will be provided) Researchers will compare the two exercise groups to see if it alters mitochondrial function.
Sex: ALL
Age: 18 Years to —
Healthy volunteers: Yes
Study type: INTERVENTIONAL
Inclusion Criteria:
* ● Healthy male or female aged over 18 years old able to give informed, written consent.
Exclusion Criteria:
* ● Current participation in a formal exercise regime
* Inability to use a static exercise bike
* A BMI \<18 or \>35 kg/m2
* Active cardiovascular disease:
* Uncontrolled hypertension (BP \> 160/100)
* Angina
* Heart failure (class III/IV)
* Significant arrhythmia
* Right to left cardiac shunt
* Recent cardiac event
* Taking beta-adrenergic blocking agents
* Cerebrovascular disease:
* Previous stroke
* Aneurysm (large vessel or intracranial)
* Epilepsy
* Respiratory disease including:
* Pulmonary hypertension
* Significant COPD
* Uncontrolled asthma
* Malignancy
* Clotting dysfunction
* Significant musculoskeletal or neurological disorders
* Any suspected or confirmed diagnosis of Covid-19- Derby, Derbyshire, United Kingdom