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Neurophysiology Biomarkers of Cognitive Impairment Associated With Deep Brain Stimulation

Active Not RecruitingNA

Sponsor: Vanderbilt University Medical Center

Conditions: Parkinson Disease

Interventions: Neural recordings and stimulation

Countries: United States

The study aims to investigate cognitive impairment associated with Deep Brain Stimulation (DBS) in Parkinson's Disease patients, with a focus on identifying neurophysiology biomarkers of DBS associated cognitive changes. Using neurophysiology data recorded during DBS surgeries and post-implantation, the research intends to identify biomarkers in order to optimize electrode placement, enhance programming, and ultimately minimize DBS-related cognitive side effects.

Eligibility overview

Sex: ALL

Age: 40 Years to —

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

• Scheduled to undergo deep brain stimulation surgery under local anesthesia at Vanderbilt University Medical Center (Arm 1)

* Active deep brain stimulation system with implantable pulse generator capable of recording local field potentials (Arm 2)
* Diagnosis of Parkinson's disease as determined by a movement disorders specialist neurologist
* Age at least 18
* Able to participate in intraoperative testing
* English speaking

Exclusion Criteria:

* Age less than 18
* Not able to participate in intraoperative testing (ex unable to comprehend instructions or follow directions)

Locations (1)

Nashville, Tennessee, United States