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Exercise Training, Cognition, and Mobility in Older Adults With Multiple Sclerosis

Active Not RecruitingNA

Sponsor: University of Illinois at Chicago

Conditions: Older Adults, Multiple Sclerosis, Cognitive Impairment, Walking Impairment

Interventions: Aerobic and Resistance Exercise Program (GEMS program), Flexibility and Stretching Program (FLEX-MS program)

Countries: United States

The overall objective of the proposed randomized controlled (RCT) is to determine the feasibility and efficacy of a 16-week theory-based, remotely-delivered, combined exercise (aerobic and resistance) training intervention for improving cognitive and physical function in older adults (50+ years) with multiple sclerosis (MS) who have mild-to-moderate cognitive and walking impairment. Participants (N=50) will be randomly assigned into exercise training (combined aerobic and resistance exercise) condition or active control (flexibility and stretching) condition. The 16-week intervention will be delivered and monitored remotely within a participant's home/community and supported by Zoom-based chats guided by social cognitive theory (SCT) via a behavioral coach. Participants will receive training materials (e.g., prescriptive manual and exercise equipment), one-on-one coaching, action-planning via calendars, self-monitoring via logs, and SCT-based newsletters. It is hypothesized that the home-based exercise intervention will yield beneficial effects on cognition, mobility, physical activity, and vascular function compared with an active control condition (flexibility and stretching intervention), and these improvements will be sustained during a 16-week follow-up period.

Eligibility overview

Sex: ALL

Age: 50 Years to —

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* Age 50 years or older
* Diagnosis of MS
* Relapse-free for the past 30 days
* Internet and e-mail access
* Ability to travel to the laboratory (for testing only)
* Willingness to complete the assessments and be randomized
* Ambulatory with or without a single-point assistive device
* Mild-to-moderate cognitive impairment (TICS-M; MSNQ)
* Walking impairment (MSWS-12)

Exclusion Criteria:

* Individuals not meeting above inclusion criteria
* Individuals with moderate to high risk for contraindications of possible injury or death when undertaking strenuous or maximal exercise (PARQ)
* Individuals diagnosed with other neurological conditions or cardiovascular diseases

Locations (1)

Chicago, Illinois, United States