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A Study to Determine the Effect of Multiple Oral Doses of SLx-2119 in Healthy Male Subjects

CompletedPhase 1

Sponsor: Kadmon, a Sanofi Company

Conditions: Immune System Disorder (Healthy Volunteer)

Interventions: Belumosudil mesylate, Placebo

Countries: United States

The purpose of this study is to determine the safety, tolerability, and pharmacokinetics of multiple doses of SLx-2119 in healthy male participants.

Eligibility overview

Sex: ALL

Age: 18 Years to 55 Years

Healthy volunteers: Yes

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* Healthy participants between the ages of 18 and 55 years, inclusive.
* Able to provide written informed consent prior to the performance of any study specific procedures.
* Body mass index (BMI) range of 19-30 kilogram per square meter (kg/m2), inclusive.

Exclusion Criteria:

* Participants are excluded from the study if any of the following criteria apply:
* Past or present disease that is judged by the investigator to have the potential to interfere with the study procedures, compromise safety, or affect the PK evaluations.
* Known sensitivity to Rho-associated coiled-coil containing serine/threonine protein kinases (ROCK2) inhibitor agents or to any of the constituents of the KD025 formulation.

The above information is not intended to contain all considerations relevant to the potential participation in a clinical trial.

Locations (1)

Baltimore, Maryland, United States