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NC Testing in LC & POTS

RecruitingNA

Sponsor: University of Calgary

Conditions: Postural Orthostatic Tachycardia Syndrome, Post Acute Sequelae of SARS CoV 2 Infection

Interventions: IV normal saline (999 mL infusion), IV normal saline (50 mL infusion)

Countries: Canada

Patients with Postural Orthostatic Tachycardia Syndrome (POTS) and Post-Acute Sequelae of COVID (PASC, or "Long COVID") experience cognitive dysfunction. The investigators will test the hypothesis that 999 mL of IV saline will improve cognitive function in patients with POTS and Long COVID compared to placebo (50 mL of saline).

Eligibility overview

Sex: ALL

Age: 18 Years to 60 Years

Healthy volunteers: Yes

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* Patients with diagnosis of Long COVID
* SARS-COV2 test positive
* Symptoms \> 12 weeks post COVID
* Subjective complaint of 'brain fog" or cognitive dysfunction
* Patients with diagnosis of Postural Orthostatic Syndrome (POTS) from the Calgary Autonomic Investigation and Management Clinic
* Subjective complaint of 'brain fog" or cognitive impairment
* Healthy participants
* Without POTS or "brain fog"
* Age 18 to 60 years
* Female and Male
* Able to give an informed consent

Exclusion Criteria:

* Patients with overt causes for POTS (e.g., dehydration, prolonged bed rest)
* An inability to safely withdraw from medicine(s) that could make test interpretation difficult and impossible.
* Other factors which are in the investigator's opinion would prevent the participant from completing the protocol, including poor compliance during previous studies or an unpredictable schedule.
* Unable to give an informed consent.

Locations (1)

Calgary, Alberta, Canada