NCT lookup

Pull any trial record directly from ClinicalTrials.gov.

Air Pollution and Cardiovascular Disease in Qatar: an Interventional Study to Reduce Blood Pressure

RecruitingNA

Sponsor: Weill Cornell Medical College in Qatar

Conditions: Hypertension, Systolic, Metabolic Syndrome

Interventions: Air cleaners with HEPA filter, Air cleaners without HEPA filter

Countries: Qatar

The main objective is to determine if in-home portable air cleaners provide persistent reductions in PM2.5 exposures and improvements in systolic blood pressure and biochemical parameters over 4-weeks in patients with metabolic syndrome residing in Qatar.

Eligibility overview

Sex: ALL

Age: 18 Years to 60 Years

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* Non-smokers (100% abstinence from use of any smoking or vaping product during the prior year)
* Age ≥18 and less than 60 years old
* Living in a single residence (home, apartment) located anywhere in Qatar
* Mild systolic hypertension: screening visit systolic BP 130 to 159 mm Hg (off treatment or taking ≤ 2 BP medications that have been stable without changes during prior 4 weeks) plus ≥ 2 more additional criteria for the metabolic syndrome:

  * Waist circumference ≥102 cm if male and ≥88 cm if female
  * Fasting triglycerides ≥150 mg/dL (or taking a triglyceride-lowering medication)
  * HDL-C ≤ 40 mg/dL if male and ≤ 50 mg/dL if female (or taking an HDL-raising medication),
  * Fasting glucose ≥100 mg/dL

Exclusion Criteria:

* Pregnancy (self-reported)
* Screening visit urine positive for cotinine (NicAlert \>100 ng/mL)
* Living with an active smoker who smokes indoors (by self-report)
* High risk conditions that prohibit allowing home BP to be \>130/80 mm Hg during the10-week trial including any cardiovascular disease (coronary artery disease, prior stroke, heart failure, peripheral arterial disease, aneurysm) or ≥ stage 3 kidney disease (estimated glomerular filtration rate \< 60 ml/min)
* A medical condition placing the participant at risk from participation (per investigators)
* Expected overnight travel outside their residence during the study
* HEPA filter within the air conditioners of the residence (self-reported) or individual use of HEPA filter
* Unable to comprehend/sign an informed consent
* Lung disease requiring oxygen
* Cancer receiving treatment
* Screening visit: BP ≥160/100 mm Hg or fasting blood glucose ≥126 mg/dL and confirmed diabetes with follow-up HbA1c ≥6.5%. If glucose is elevated ≥126 mg/dL but HbA1c\<6.5%, they could still participate.
* Medication changes in past 4 weeks. If participants are on medications for high BP or hyperlipidemia, they will need to have had stable therapy during prior 10 weeks with no planned changes during the study
* Left upper arm circumference \>17 inches as this will make BP levels inaccurate with the home monitor used
* Acute illness or infectious symptoms within the prior 4 weeks.

Locations (1)

Doha, Qatar