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MS Fatigue and tDCS on Fatigue in Multiple Sclerosis

CompletedNA

Sponsor: Assistance Publique - Hôpitaux de Paris

Conditions: Fatigue in Multiple Sclerosis

Interventions: Real left prefrontal tDCS - sham, Sham - Real left prefrontal tDCS

Countries: France

The available therapeutic strategies for Multiple Sclerosis (MS)-related symptoms are usually faced with limited efficacy and numerous side effects. Patients with MS frequently suffer from fatigue, affective symptoms, and cognitive deficits.

Eligibility overview

Sex: ALL

Age: 18 Years to 75 Years

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* Definite MS diagnosis according to the 2017 McDonald criteria
* Fatigue since more than 6 months as assessed by fatigue severity scale (FSS\>5)
* Age between 18 and 75 years.
* Stable pharmacological and physical treatment since at least one month
* Affiliation to the social security regimen
* Signature of the informed consent
* Ability of the patient to understand the instructions for use of the pacemaker to ensure safe use

Exclusion Criteria:

* Relapses within the last two months
* Active medical device implanted
* Intracranial metal implants
* Craniotomy, cranial trepanation, aneurysm
* Uncontrolled epilepsy
* Non-weaned alcoholism, sleep debt
* Expanded disability status scale ≥ 6.5
* Severe depression based on Beck Depression inventory (BDI\>19)
* Daytime sleepiness based on Epworth Sleepiness Scale (ESS\> 11)
* Other neurologic and psychiatric diseases
* Known pregnancy by the investigator or breastfeeding
* Physical or mental incapacity to give informed consent
* Participation in another study (exclusion period following a previous study should be ≥ 6 months)
* Patients on AME
* Patients under legal protection
* Prisoners

Locations (1)

Créteil, France