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A Study of Retatrutide (LY3437943) in Participants With Obesity and Cardiovascular Disease

NCT05882045

CompletedPhase 3

Sponsor: Eli Lilly and Company

Conditions: Obesity, Cardiovascular Diseases

Interventions: Retatrutide, Placebo

Countries: United States, Argentina, Australia, Canada, Hungary, Mexico, Poland, Puerto Rico

The main purpose of this study is to evaluate the efficacy and safety of retatrutide once weekly in participants with obesity and established cardiovascular disease (CVD). The study will last about 113 weeks.

Eligibility overview

Sex: ALL

Age: 18 Years to —

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* Have a body mass index (BMI) ≥35.0 kilogram/square meter (kg/m²).
* Have established cardiovascular (CV) disease with at least 1 of the following:

  * prior myocardial infarction
  * prior ischemic or hemorrhagic stroke, or
  * symptomatic peripheral arterial disease
* Have a history of at least 1 self-reported unsuccessful dietary effort to reduce body weight.

Exclusion Criteria:

* Have had acute myocardial infarction, stroke, coronary revascularization, hospitalization for unstable angina, or hospitalization due to congestive heart failure within 90 days prior to screening.
* Have taken weight loss drugs, including over-the-counter medications, within 90 days prior to screening.
* Have a prior or planned surgical treatment of obesity.
* Have a change in body weight greater than 5 kg (11 pounds) within 90 days prior to screening.
* Have Type 1 diabetes.
* Have family or personal history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN-2)
* Have had pancreatitis.

Locations (169)

Phoenix, Arizona, United States
Covina, California, United States
Fresno, California, United States
Fresno, California, United States
Los Alamitos, California, United States
Los Angeles, California, United States
Northridge, California, United States
Van Nuys, California, United States
Waterbury, Connecticut, United States
Hialeah, Florida, United States
Jacksonville, Florida, United States
Orlando, Florida, United States
Orlando, Florida, United States
Port Orange, Florida, United States
Honolulu, Hawaii, United States
Blackfoot, Idaho, United States
Boise, Idaho, United States
Chicago, Illinois, United States
Gurnee, Illinois, United States
Springfield, Illinois, United States
Indianapolis, Indiana, United States
West Des Moines, Iowa, United States
Topeka, Kansas, United States
Waltham, Massachusetts, United States
City of Saint Peters, Missouri, United States
Las Vegas, Nevada, United States
Las Vegas, Nevada, United States
Warren Township, New Jersey, United States
New York, New York, United States
Rochester, New York, United States
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