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Comparing the Diagnostic Sensitivity and Specificity of Pleural Fluid N-Terminal Pro B-type Natriuretic Peptide (NT-proBNP) and Other Biochemical Gradient Criteria in Distinguishing Heart Failure and Non-heart Failure Related Pleural Effusions (CENTRE Study)

NCT05797649

RecruitingN/A

Sponsor: Chinese University of Hong Kong

Conditions: Pleural Effusion, Heart Failure, Malignant Neoplasm, Fluid Overload, Hypoalbuminemia

Countries: Hong Kong

To assess the discriminative properties of pleural fluid (PF) N-terminal-proB-type-natriuretic-peptide (NTproBNP) levels in identifying heart failure (HF)-associated pleural effusions (PE).

Eligibility overview

Sex: ALL

Age: 18 Years to —

Healthy volunteers: No

Study type: OBSERVATIONAL

Eligibility criteria

Inclusion Criteria:

* Patients hospitalized for heart failure and pleural effusion
* Pleural tapping indicated for pleural fluid analysis.
* Aged 18 years old or above

Exclusion Criteria:

* History of intrapleural therapy (including talc and fibrinolytic) in the ipsilateral pleural space.
* History of surgical decortication or pleurodesis in the ipsilateral pleural space.
* Ipsilateral thoracic or cardiac surgery in the past 3 months.
* Failure to obtain informed consent due to the patient's refusal or cognitive impairment.

Locations (1)

Hong Kong, New Territories, Hong Kong