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Walking and Thinking - Brain Activity During Complex Walking in People With Multiple Sclerosis

CompletedN/A

Sponsor: Karolinska Institutet

Conditions: Multiple Sclerosis, Gait Disorders, Neurologic, Neuro-Degenerative Disease, Aging

Interventions: No intervention

Countries: Sweden

Every-day life means being part of a complex environment and performing complex tasks that usually involve a combination of motor and cognitive skills. However, the process of aging or the sequelae of neurological diseases such as Multiple Sclerosis (MS) compromises motor-cognitive interaction necessary for an independent lifestyle. While motor-cognitive performance has been identified as an important goal for sustained health across different clinical populations, little is known about underlying brain function leading to these difficulties and how to best target these motor-cognitive difficulties in the context of rehabilitation and exercise interventions. The challenge of improving treatments of motor-cognitive difficulties (such as dual-tasking and navigation) is daunting, and an important step is arriving at a method that accurately portrays these impairments in an ecological valid state. The investigators aim therefore to explore brain function during complex walking in MS (in comparison with people with Parkinson's disease and healthy controls) by investigating the effects of neurological disease on motor-cognitive performance and its neural correlates during three conditions of complex walking (dual-task walking, navigation and a combination of both) using non-invasive measures of brain activity (functional near infrared spectrometry, fNIRS) and advanced gait analysis in real time in people with MS (in comparison with people with Parkinson's disease and healthy adults).

Eligibility overview

Sex: ALL

Age: 18 Years to —

Healthy volunteers: No

Study type: OBSERVATIONAL

Eligibility criteria

Inclusion Criteria:

* 18 years or older
* with an MS diagnosis according to McDonald criteria
* with the ability to walk without a mobility device for ≥5 minutes continuously.

Exclusion Criteria:

* Disease or condition that affects cognition, gait or balance.
* MS relapse or change of disease-modifying treatment within the past eight weeks.

Locations (1)

Stockholm, Solna, Sweden