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Inclusion Criteria:

* Histologically confirmed, unresectable advanced or metastatic biliary tract carcinoma (BTC) including cholangiocarcinoma (intrahepatic or extrahepatic), gallbladder carcinoma, and ampulla of Vater (AoV) carcinoma
* Participants with unresectable or metastatic BTC
* A World Health Organisation Eastern Cooperative Oncology Group Performance Status (WHO/ECOG PS) of 0 to 2
* At least one lesion that qualifies as a Response Evaluation Criteria in Solid Tumours version 1.1 (RECIST 1.1) target lesion at baseline
* Adequate organ and bone marrow function
* Body weight of \> 30 kg
* Negative pregnancy test (serum) for women of childbearing potential
* Female participants must be one year post-menopausal (amenorrhoeic for 12 months without an alternative medical cause)
* Male and female participants and their partners must be surgically sterile or on their chosen method of birth control as per the protocol.

Exclusion Criteria:

* Any evidence of diseases such as severe or uncontrolled systemic diseases, including uncontrolled hypertension, active bleeding diseases, active infection, active interstitial lung disease/pneumonitis, serious chronic gastrointestinal conditions associated with diarrhoea, psychiatric illness/social situations, history of uncontrolled or symptomatic cardiac disease, and history of allogenic organ transplant
* Active or prior documented autoimmune or inflammatory disorders
* History of another primary malignancy, except for malignancy treated with curative intent and with no known active disease ≥ 5 years before the first dose of study intervention
* History of leptomeningeal carcinomatosis
* History of active primary immunodeficiency
* Known to have tested positive for human immunodeficiency virus \[HIV\] (positive HIV 1/2 antibodies) or active tuberculosis infection
* Participants co-infected with Hepatitis B virus (HBV) and Hepatitis C virus (HCV) or co-infected with HBV and Hepatitis D virus (HDV)
* Persistent toxicities (Common Terminology Criteria for Adverse Events \[CTCAE\] Grade \> 1) caused by previous anticancer therapy
* Central nervous system metastases requiring treatment or history of spinal cord compression
* Known allergy or hypersensitivity to any of the study intervention or any of the study intervention excipients.
* Any concurrent chemotherapy, other than the one allowed in the study, investigational medicinal product (IMP), biologic, or hormonal therapy for cancer treatment
* Palliative radiotherapy with a limited field of radiation within 2 weeks of the first dose of study intervention, or radiotherapy with a wide field of radiation or radiotherapy affecting more than 30% of the bone marrow within 4 weeks before the first dose of study intervention
* Receipt of live attenuated vaccine within 30 days prior to the first dose of study intervention
* Major surgical procedure within 28 days prior to the first dose of IMP
* Prior exposure to immune-mediated therapy excluding therapeutic anticancer vaccines
* Receipt of the last dose of anticancer therapy within 28 days prior to the first dose of IMP

• Mobile, Alabama, United States
• Orange, California, United States
• Washington D.C., District of Columbia, United States
• Portland, Oregon, United States
• Clichy, France
• Dijon, France
• Montpellier, France
• Villejuif, France
• Chemnitz, Germany
• Hanover, Germany
• Castelfranco Veneto, Italy
• Foggia, Italy
• Palermo, Italy
• Pisa, Italy
• Rozzano, Italy
• Chūōku, Japan
• Kanazawa, Japan
• Kashiwa, Japan
• Kyoto, Japan
• Osaka, Japan
• Sendai, Japan
• Ube, Japan
• Wakayama, Japan
• Yokohama, Japan
• Singapore, Singapore
• Seoul, South Korea
• Seoul, South Korea
• Seoul, South Korea
• Barcelona, Spain
• Madrid, Spain
• + 4 more on CT.gov