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High-intensity Interval Exercise in Rheumatoid Arthritis

Active Not RecruitingNA

Sponsor: Vastra Gotaland Region

Conditions: Rheumatoid Arthritis

Interventions: High intensity exercise

Countries: Sweden

Cardiovascular performance and overall fitness can be improved by high-intensity aerobic activity, and these benefits may be achievable by persons with rheumatic diseases. The investigators hypothesize that a 12-week high-intensity interval exercise program will provide substantial improvements in cardiovascular function, inflammation and symptoms affecting quality of life.

Eligibility overview

Sex: ALL

Age: 20 Years to 60 Years

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* Rheumatoid arthritis disease according to the American College of Rheumatology (ACR)/ The European Alliance of Associations for Rheumatology (EULAR) 1987/2010 criteria
* Disease duration \>1 year
* Age (range 20-60 years)
* Stable medication on anti- rheumatic drugs for \>3 months
* Low-to-moderate disease activity (\<5.1) according to the Disease activity score 28 (DAS28)

Exclusion Criteria:

* Cerebrovascular diseases
* Diabetes
* Severe hypertension
* Chronic obstructive pulmonary disease or other severe pulmonary diseases
* Other severe diseases that may be associated with adverse events or restrict participation in high-intensity exercise
* Arthroplasty of large joints
* Inability to manage Cardiopulmonary Exercise Testing (CPET)
* Pregnancy
* Already participating in regular aerobic or strength exercise at a high intensity level (\>1 hours/ week) during the last 6 months
* Inability to speak or read Swedish.

Locations (2)

Gothenburg, Sweden
Uddevalla, Sweden