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Acromegaly: Balance, Falls and Fracture Risk

CompletedN/A

Sponsor: Christian Alexander H Rosendal

Conditions: Acromegaly

Interventions: HR-pQCT, DXA scan, Bone microindentation, Hand grip and leg extension strength, Timed up-and-go test

Countries: Denmark

The goal of this observational, cross-sectional study is to study bone quality, joint quality and fall risk in acromegalic patients, compared with healthy controls. The main questions it aims to answer are: * what is the optimal method for evaluating bone quality and fracture risk in acromegalic patients? * are acromegalic patients at increased risk of falling? * is HR-pQCT a feasible method for evaluating acromegalic joint disease? Participants will undergo HR-pQCT scans, DXA scans, OsteoProbe examination and fall risk assessments. Results will be compared to matched healthy controls.

Eligibility overview

Sex: ALL

Age: 18 Years to 99 Years

Healthy volunteers: Yes

Study type: OBSERVATIONAL

Eligibility criteria

Inclusion Criteria:

1. Verified acromegaly diagnosis
2. Age \>18 years
3. Ability to provide informed consent
4. Ability to stand on both legs for \>5 minutes at a time and walk \>6 meters
5. Patient is eugonadal, either naturally or by hormone replacement therapy

Exclusion Criteria:

1. Established diagnosis of severe kidney or liver dysfunction, malabsorption, multiple myeloma or other diseases associated with reduced bone quality
2. Treatment with supraphysiological doses of glucocorticoids or other drugs that impair bone quality
3. Diagnosis of rheumatoid arthritis, psoriatic arthritis or other joint diseases unrelated to acromegaly
4. Active drug or alcohol abuse
5. Pregnancy
6. Known allergy/hypersensitivity to local anaesthetics or disinfectant
7. Other factors that render the subject unable to participate in the clinical study, based on the judgment of the investigator(s)

Locations (1)

Aalborg, North Denmark, Denmark