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Cognitive Reserve-building Activities in Multiple Sclerosis

CompletedPhase 2

Sponsor: Rigshospitalet, Denmark

Conditions: Multiple Sclerosis

Interventions: Cognitive Leisure Activities

Countries: Denmark

The study is a crossover randomized controlled trial investigating the effect of increasing engagement in cognitive leisure activities for individuals with multiple sclerosis.

Eligibility overview

Sex: ALL

Age: 18 Years to 65 Years

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* RRMS, SPMS or PPMS
* Age 18-65
* EDSS score ≤ 6.5
* SDMT (or PASAT) score below -1 SD
* No depression based on the MDI
* Able to use computer or smartphone and has internet access
* If in treatment with one or more of the following medications, the dosage must be stable:

  * Cannabinoids
  * Anticholinergic medications
  * Sedatives e.g., benzodiazepines
  * Opioids
  * Antispasmodics
  * Beta-blockers
  * Antidepressant medication
  * Fampridine

Exclusion Criteria:

* Planned start-up or discontinuation of one or more of the above-mentioned medications
* Structural brain changes following previous head trauma or neurological conditions other than which lead to structural changes or affect cognitive abilities
* Epilepsy
* Significant psychiatric co-morbidity
* Significant somatic co-morbidity including, but not limited to, severe cardiovascular disease as well as liver, kidney, and endocrine diseases
* Relapse 3 months prior to inclusion

Locations (1)

Glostrup Municipality, Denmark