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Inclusion Criteria:

* Provision of signed and dated, written informed consent prior to any study specific procedures, sampling and analyses.
* Males and females aged ≥ 18 years at the time of screening.
* Patients with documented evidence of locally advanced unresectable or metastatic solid tumours, excluding lymphoma, who have exhausted standard of care options (or for which no standard therapies exist) and may be suitable for AZD5305 monotherapy treatment.
* Adequate organ and marrow function.
* An Eastern Cooperative Oncology Group Performance Status (ECOG PS): 0 to 2 with no deterioration over the previous 2 weeks.
* Life expectancy ≥ 12 weeks.
* Female patients of childbearing potential. Must have a negative pregnancy test result at screening and prior to each Part of study intervention.
* Female patients must not breastfeed and must not donate or retrieve ova for their own use from screening to approximately 6 months after the last dose of study intervention.

Exclusion Criteria:

* Previous enrolment in the present study (ie, dosing with AZD5305 previously initiated in this study).
* Positive for detection of drugs of abuse or alcohol at screening.
* Concomitant use of medications or herbal supplements known to be cytochrome P450 3A4 enzyme (CYP3A4) substrates, strong, and moderate inhibitors or inducers.
* Patients with germline Breast cancer gene-mutated relapsed advanced ovarian cancer who have received three or more previous lines of chemotherapy.
* Using of proton pump inhibitors, histamine H2 receptor antagonists and other antiacid agents.
* Using of calcium channel blockers.
* Concomitant use of drugs that are known to prolong or shorten QT and have a known risk of Torsade's de Pointes (TdP).
* During the 4 weeks prior to the first dose, receiving continuous corticosteroids.
* Major surgery within 4 weeks of the first dose of study intervention.
* Radiotherapy with a wide field of radiation within 4 weeks or radiotherapy with a limited field of radiation for palliation within 2 weeks of the first dose of study intervention.
* Treatment with any of the following: any investigational agents or study interventions from a previous clinical study within 5 half-lives or 3 weeks (whichever is shorter) of the first dose of study intervention; any other anticancer treatment within the following time periods prior to the first dose of study intervention: Cytotoxic and non-cytotoxic treatment: 3 weeks or five half-lives (whichever is shorter); Biological products including immuno-oncology agents: 4 weeks before enrolment.; any live virus or bacterial vaccine within 28 days of the first dose of study intervention.
* Any concurrent anticancer therapy or concurrent use of prohibited medications.
* With the exception of alopecia, and peripheral neuropathy; any unresolved toxicities from prior therapy greater than CTCAE Grade 1.
* Any known history of persisting (\> 2 weeks) severe pancytopenia.
* Spinal cord compression, or brain metastases unless asymptomatic and treated and stable and not requiring continuous corticosteroids at a dose of \> 10 mg prednisone/day or equivalent.
* Any evidence of severe or uncontrolled systemic diseases, including, active bleeding diatheses, or active infection including hepatitis B, hepatitis C and human immunodeficiency virus.
* Patients with any known predisposition to bleeding.
* Any of the following cardiac criteria: mean resting QTcF \> 450 ms or QTcF \< 340 ms obtained from triplicate ECGs and averaged, recorded within 5 minutes; any factors that increase the risk of QT prolongation, shortening or risk of arrhythmic events such as hypokalaemia, congenital long or short QT syndrome, family history of long QT syndrome, familial short QT syndrome, or unexplained sudden death under 40 years of age; any clinically important abnormalities in rhythm, conduction or morphology of resting ECG eg, complete left bundle branch block, second- or third-degree atrioventricular block, and clinically significant sinus node dysfunction not treated with pacemaker.
* Other cardiovascular diseases.
* Patients with history of MDS/AML or with features suggestive of MDS/AML.
* Refractory nausea and vomiting, chronic GI diseases, inability to swallow the formulated product or previous significant bowel resection that would preclude adequate absorption of AZD5305.
* Known allergy or hypersensitivity to investigational product(s) or any of the excipients of the investigational product(s).
* Any condition that, in the opinion of the Investigator, would interfere with evaluation of the study intervention or interpretation of patient safety or study results.
* Past medical history of interstitial lung disease (ILD), drug-induced ILD, radiation pneumonitis which required steroid treatment, or any evidence of clinically active ILD.
* Uncontrolled intercurrent illness within the last 12 months.

• Chisinau, Moldova
• Cluj-Napoca, Romania