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Safety and Efficacy of ALXN1720 in Adults With Generalized Myasthenia Gravis
Safety and Efficacy of ALXN1720 in Adults With Generalized Myasthenia Gravis

NCT05556096

Active Not RecruitingPhase 3

Sponsor: Alexion Pharmaceuticals, Inc.

Conditions: Generalized Myasthenia Gravis

Interventions: ALXN1720, Placebo

Countries: United States, Argentina, Austria, Brazil, Canada, China, Denmark, France

The purpose of this study is to evaluate the safety and efficacy of ALXN1720 for the treatment of generalized MG (gMG) in adults with autoantibodies against acetylcholine receptor (AChR).

Eligibility overview

Sex: ALL

Age: 18 Years to —

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria
Inclusion Criteria:

* Diagnosis of MG with generalized muscle weakness meeting the clinical criteria defined by Myasthenia Gravis Foundation of America (MGFA) Class II, III or IV
* Positive serological test for autoantibodies against AChR

Exclusion Criteria:

* History of thymectomy, or any other thymic surgery within 12 months prior to Screening
* Untreated thymic malignancy, carcinoma, or thymoma
* History of Neisseria meningitidis infection
* Pregnancy, breastfeeding, or intention to conceive during the course of the study
Locations (132)
  • Orange, California, United States
  • Fort Collins, Colorado, United States
  • Washington D.C., District of Columbia, United States
  • Bradenton, Florida, United States
  • Maitland, Florida, United States
  • Tampa, Florida, United States
  • Augusta, Georgia, United States
  • Gainesville, Georgia, United States
  • Savannah, Georgia, United States
  • Springfield, Illinois, United States
  • Kansas City, Kansas, United States
  • Lexington, Kentucky, United States
  • Detroit, Michigan, United States
  • East Lansing, Michigan, United States
  • Las Vegas, Nevada, United States
  • Patchogue, New York, United States
  • Rochester, New York, United States
  • Syracuse, New York, United States
  • Chapel Hill, North Carolina, United States
  • North Charleston, South Carolina, United States
  • Houston, Texas, United States
  • Richmond, Virginia, United States
  • Morgantown, West Virginia, United States
  • CABA, Argentina
  • Ciudad de Buenos Aires, Argentina
  • Ciudad de Buenos Aires, Argentina
  • Ciudad de Buenos Aires, Argentina
  • Rosario, Argentina
  • Innsbruck, Austria
  • Wels, Austria
  • + 102 more on CT.gov