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Cognitive Markers in Prodromal MS

CompletedNA

Sponsor: NYU Langone Health

Conditions: Multiple Sclerosis

Interventions: Active tDCS

Countries: United States

The focus of this work is the evaluation of a measure of cognitive functioning- intra-individual variability (IIV) - derived from a computer-based continuous reaction time (RT) task (Cogstate) as an early marker of prodromal MS.

Eligibility overview

Sex: ALL

Age: 23 Years to 59 Years

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* Ages 23-59 years old (inclusive)
* Prodromal MS (defined by radiologically isolated syndrome ≤ 6 months from first MRI or clinically isolated syndrome ≤ 3 months from first clinical event)

Exclusion Criteria:

* Below average estimated premorbid cognitive functioning (based on WRAT-4 reading recognition standard z-score \< 85).
* Presence of severe cognitive impairment (based on SDMT age normative z-score \<-3.0).
* Primary psychiatric disorder that would influence ability to participate.
* Current uncontrolled seizure disorder.
* Current substance abuse disorder.
* History of head trauma in the past year (e.g., head injury, brain surgery) or medical device implanted in the head (such as Deep Brain Stimulator) or in the neck (such as a Vagus Nerve Stimulator).
* Pregnant or breastfeeding

Additional Exclusion Criteria for tDCS-MRI Participants

* Extreme claustrophobia
* Any skin disorder/sensitive skin (e.g., eczema, severe rashes), blisters, open wounds, burn including sunburns, cuts or irritation, or other skin defects which compromise the integrity of the skin at or near stimulation locations (where electrodes are placed)
* Treatment for a communicable skin disorder currently or over the past 12 months
* Have any irremovable piercings, metallic based-tattoos, or MRI-contraindicated implants (e.g. pacemakers and defibrillators)

Locations (1)

New York, New York, United States