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Longitudinal Multimodal Response Assessment During Neoadjuvant Treatment of Rectal Cancer

Active Not RecruitingN/A

Sponsor: Jena University Hospital

Conditions: Locally Advanced Rectal Carcinoma, Neoadjuvant Treatment, Radiotherapy, Adaptive Treatment

Interventions: Blood sample, MRI scan

Countries: Germany

This pilot study aims to trial multimodal early response assessment to enable therapy adaptions in the context of non-operative therapy strategies of locally advanced rectal cancer (LARC) for development of a non-invasive response prediction model.

Eligibility overview

Sex: ALL

Age: 18 Years to —

Healthy volunteers: No

Study type: OBSERVATIONAL

Eligibility criteria

Inclusion Criteria:

* locally advanced rectal cancer (LARC): UICC Stage II/III
* no severe cardiac or lung disease
* no severe hepatic disorders (liver enzymes \<2.5 NR) or restrictions of renal function (GFR \> 30ml/min)
* no severe cytopenia (Neutrocytes \>= 3 Gpt/l; Thrombocytes \>= 100 Gpt/l; Hemoglobin \>6mmol/l)
* no homozygotic DPD deficiency
* no other neoplasms requiring therapy
* no earlier radiotherapy of the pelvis or earlier chemotherapy
* no contraindications for MRI

Locations (1)

Jena, Germany