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Safety and Immunogenicity of Pneumococcal Conjugate Formulations in Healthy Adults 18 Through 49 Years of Age

CompletedPhase 1

Sponsor: Pfizer

Conditions: Pneumococcal Disease

Interventions: Candidate-1, Candidate-2, Candidate-3, Candidate-4, Candidate-5

Countries: United States

The purpose of the study is to describe the safety and immunogenicity of Pneumococcal Conjugate Formulations in healthy adults 18 through 49 years of age.

Eligibility overview

Sex: ALL

Age: 18 Years to 49 Years

Healthy volunteers: Yes

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* Male or female participants ≥18 and ≤49 years of age at the time of consent
* Adults determined by clinical assessment to be eligible for the study, including adults with preexisting stable disease within 12 weeks before receipt of study intervention
* Participants willing to use acceptable contraception for at least 28 days after study intervention; female participants not of childbearing potential; male participants unable to father children

Exclusion Criteria:

* History of severe adverse reaction associated with a vaccine and/or severe allergic reaction to any component in pneumococcal conjugate vaccines and any other diphtheria toxoid-containing vaccine
* Serious chronic disorder that in the investigator's opinion would make the participant inappropriate for entry into the study
* Medical or psychiatric condition (recent or active suicidal ideation/behavior or laboratory abnormality) that may increase risk of study participation or make participant inappropriate for the study
* Known or suspected immunodeficiency or other conditions associated with immunosuppression
* Previous vaccination with any licensed or investigational pneumococcal vaccine, or planned receipt of any licensed or investigational pneumococcal vaccine through study participation
* Receipt of any inactivated or otherwise nonlive vaccine within 14 days or any live vaccine within 28 days before administration of study intervention

Locations (18)

Tustin, California, United States
Walnut Creek, California, United States
Milford, Connecticut, United States
Fort Lauderdale, Florida, United States
Hialeah, Florida, United States
South Miami, Florida, United States
Elkridge, Maryland, United States
Troy, Michigan, United States
Saint Paul, Minnesota, United States
Somers Point, New Jersey, United States
Wilmington, North Carolina, United States
San Antonio, Texas, United States
San Antonio, Texas, United States
San Antonio, Texas, United States
Tomball, Texas, United States
Salt Lake City, Utah, United States
Salt Lake City, Utah, United States
Norfolk, Virginia, United States