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Neural Mechanisms of Clinically Designed Improvisatory Music for Alzheimer's Disease

Enrolling By InvitationNA

Sponsor: Northwestern University

Conditions: Alzheimer Disease

Interventions: Clinically Designed Improvisatory Music

Countries: United States

Clinically Designed Improvisatory Music (CDIM) is a form of improvised music based on calm-inducing sound parameters which brought relief to our cohort of neurology patients. As a direct sound-based approach, CDIM does not rely on autobiographical memory and may have wider applicability and generalizability. We wish to examine if CDIM decreases anxiety in 15 cognitively healthy individuals and 15 Alzheimer Disease patients with anxiety (AD-A).

Eligibility overview

Sex: ALL

Age: 55 Years to 100 Years

Healthy volunteers: Yes

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

1. Cognitively healthy individuals

   Cognitively healthy control participants evaluated through the Northwestern Mesulam Center. BAI \> 8.

   Exclusion Criteria: hearing loss
2. Individuals with mild to moderate Alzheimer's disease

This group will similarly be recruited through the Mesulam Center. All individuals recruited by the research Core at the center are well characterized tests standardized across all NIH funded Alzheimer Centers across the nation. Individuals with mild to moderate neurocognitive disorder due to AD will have an MMSE greater than \>15 and Clinical Dementia Rating (CDR) between 0.5 and 2.. They will also have a history of neurocognitive-related agitation/anxiety, and a Beck Anxiety Index (BAI) or Rating for Anxiety in Dementia (RAID) greater than 8, suggestive of at least a mild level of anxiety.

Exclusion criteria: MMSE\<15, CDR\>2, hearing loss

Locations (1)

Chicago, Illinois, United States