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Sustained Release Oral Formulation for Treatment of Parkinson's Disease

CompletedEARLY_Phase 1

Sponsor: University of Minnesota

Conditions: Healthy Volunteers

Interventions: levodopa/carbidopa oral formulation A, levodopa/carbidopa oral formulation B

Countries: United States

Achieving sustained blood levels of carbidopa/levodopa has been a challenge in the treatment of PD and although levodopa remains the most commonly used drug, motor fluctuations remain a major disability especially in advanced Parkinson's disease. The aim of this study is to determine the efficacy of a novel oral carbidopa-levodopa formulation in achieving a sustained blood level of levodopa and carbidopa in normal volunteers.

Eligibility overview

Sex: ALL

Age: 18 Years to 65 Years

Healthy volunteers: Yes

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* Normal healthy
* Are 18-65 years of age
* Are not currently taking medications regularly
* Able to fast 6 hours (water allowed)

Exclusion Criteria:

* Pregnancy
* Inability to fast

Locations (1)

Minneapolis, Minnesota, United States