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Long-term COVID and Rehabilitation

RecruitingNA

Sponsor: VA Office of Research and Development

Conditions: Long-COVID

Interventions: Mitoquinone, Placebo

Countries: United States

The proposed focuses on improving both morbidity and mortality in older Veterans and those recovering from COVID-19 by developing rehabilitation therapies to augment vascular endothelial function by combating the oxidative stress and inflammation associated with aging and further induced by COVID-19. The investigators expected outcomes will have an important positive impact because they will provide scientifically sound recommendations for rehabilitation to improve vascular endothelial function and minimize the long-term consequences of COVID-19.

Eligibility overview

Sex: ALL

Age: 18 Years to —

Healthy volunteers: Yes

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* Long-COVID and COVID-recovered patients must have SARS-CoV-19 positive test near the time of COVID-19 diagnosis
* Long-COVID and COVID-recovered patients must be 3-12 months post-initial COVID-19 diagnosis
* Ability to sign informed consent

Exclusion Criteria:

* BMI \>45 kg/m2
* Unstable (\<6 months) or severe coronary artery disease (CAD-RADS score = 4A), peripheral artery disease (Ankle Brachial Index \<0.40), cerebrovascular disease (identified by previous stroke in last 12 months), severe COPD (=Stage III), uncontrolled hypertension (\>160/100 mmHg), chronic kidney disease requiring dialysis, severe renal insufficiency (creatinine clearance \<30 by the Cockcroft-Gault formula), Alzheimer's disease, dementia
* Orthopedic limitations that would prohibit exercise
* Current smokers and individuals that stopped smoking in the last 10 years
* Already taking Mito-Q or unwilling to cease dietary supplements for participation
* Any other condition or event considered exclusionary by the PIs or a physician

Locations (1)

Salt Lake City, Utah, United States