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Accelerated Transcranial Magnetic Stimulation (TMS) for Smoking Cessation in People Living With HIV/AIDS (PLWHA)

CompletedNA

Sponsor: Gopalkumar Rakesh

Conditions: Hiv, Tobacco Smoking

Interventions: TBS, Sham TMS

Countries: United States

To demonstrate whether four sessions of TBS improves attentional bias and craving in PLWHA smokers compared to four sessions of sham stimulation. We hypothesize 4 sessions of TBS to the left DLPFC will significantly improve attentional bias and craving for smoking cues compared to neutral cues in a population of subjects who are smokers with HIV/AIDS compared to sham stimulation.

Eligibility overview

Sex: ALL

Age: 18 Years to 60 Years

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria: Potential participants will be

* Patients enrolled in the Bluegrass Clinic
* 18-60 years of age
* Male or female gender
* Able to read, understand and communicate in English
* Willing to adhere to the general rules of the Bluegrass Clinic/SMARTClinic/Beyond Birth Clinic
* Willing and able to abstain from drug use other than Suboxone
* Exhaled breath on day of study carbon monoxide (CO) \< 5 ppm
* Stabilized on maintenance buprenorphine if having comorbid opioid use disorder.

Exclusion Criteria:

* Positive pregnancy test for females, traumatic brain injury, history of seizure disorder, history of or current diagnosis of schizophrenia, intracranial metal shrapnel.
* Previous adverse effect with TMS.
* Sub-threshold consistency while performing behavioral tasks.
* Failure to show baseline attentional bias to smoking versus neutral cues.

Locations (2)

Lexington, Kentucky, United States
Lexington, Kentucky, United States