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Complex Molecular Etiology and Cellular Landscape of Hip Osteoarthritis

RecruitingN/A

Sponsor: University of Turku

Conditions: Osteoarthritis, Hip, Rheumatoid Arthritis

Interventions: Total hip arthroplasty

Countries: Finland

The purpose of this study is to cast light on the highly complex etiology and cellular landscape of hip osteoarthritis by utilising single-cell and spatial omics.

Eligibility overview

Sex: ALL

Age: 18 Years to 74 Years

Healthy volunteers: Yes

Study type: OBSERVATIONAL

Eligibility criteria

Inclusion Criteria for the main (OA) study:

Cases: Adult patients with osteoarthritis in the hip joint and who are going through an elective total hip arthroplasty.

Controls: Non-arthritis adult patients who are going through a trauma-based emergency total hip arthroplasty.

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Inclusion Criteria for the Rheumatoid sub-study:

Adult patients with rheumatoid arthritis in the hip joint and who are going through an elective total hip arthroplasty.

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Exclusion Criteria:

* The body mass index must be below 35
* Age \< 18 or \> 74
* The OA patients may not have diabetes, rheumatoid arthritis (RA), or metabolic syndrome.

For the Rheumatoid sub-study, the exclusion criteria are the same as above except for the RA.

Locations (4)

Turku, Southwest Finland, Finland
Turku, Southwest Finland, Finland
Turku, Southwest Finland, Finland
Espoo, Uusimaa, Finland