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Inclusion Criteria

* Part 1: Breast Cancer (BC)
* HR+, HER2- BC
* Refractory HR-positive/HER2-positive BC
* Part 1: Solid Tumors other than BC
* Part 2:
* HR-positive/HER2-negative BC
* Lesion:
* Part 1: evaluable lesion (including skin or bone lesion only)
* Part 2: measurable lesion per RECIST v1.1
* Prior systemic Treatment
* Part 1: HR-positive/HER2-negative BC
* At least 1 line of SOC, including CDK4/6 inhibitor therapy and Endocrine Therapy, for advanced or metastatic disease.
* Prior chemotherapy in the metastatic setting is allowed.
* Part 1: HR-positive/HER2-positive BC
* At least 1 prior treatment of approved HER2 targeting therapy.
* Part 1: Solid Tumors other than BC
* Participants with no standard therapy available or for which no local regulatory approved standard therapy is available that would confer significant clinical benefit in the medical judgement of the investigator.
* Part 2A: At least 1 prior systemic therapy for advanced or metastatic disease, including CDK4/6 inhibitor treatment and ET.
* Parts 2B: At least 1 prior endocrine therapy for advanced or metastatic disease. Progression during treatment or within 12 months of completion of adjuvant endocrine therapy is acceptable.
* Part 2B: Up to 1 prior line of chemotherapy for advanced/metastatic disease is allowed.
* General Inclusion Criteria
* Eastern Cooperative Oncology Group (ECOG) Performance Status (PS) 0 or 1
* Adequate renal, liver, and bone marrow function
* Resolved acute effects of any prior therapy to baseline severity

Exclusion Criteria:

* All Study Parts: Permanent treatment discontinuation from prior CDK 4 and/or CDK2 inhibitor due to treatment related toxicity.
* Part 2B and 1C: Prior treatment with any CDK 4/6 inhibitor, or SERDs (e.g. fulvestrant), or everolimus, or any agent whose mechanism of action is to inhibit the PI3K-mTOR pathway for advanced disease.
* Parts 2B and 2C: Prior treatment with any CDK4/6 inhibitor for advanced disease.
* Parts 2B and 2C: Prior treatment with an investigational endocrine therapy for advanced disease.
* Part 2C: Prior neoadjuvant or adjuvant treatment with a nonsteroidal aromatase inhibitor AI (ie, anastrozole or letrozole) with disease recurrence while on or within 12 months of completing treatment.
* Part 2C: Any prior systemic treatment for advanced disease.
* Prior irradiation to \>25% of the bone marrow
* Current use of drugs which have a risk for QTc prolongation
* Current use or anticipated need for food or drugs that are known strong CYP3A4/5, strong UGT2B7 or UGT1A9 inhibitors or inducers
* Participation in other studies involving investigational drug(s) within 4 weeks prior to study entry

  * Participants with any other active malignancy within 3 years prior to enrollment except for adequately treated basal cell or squamous cell skin cancer, or carcinoma in situ of the cervix, Bowen's disease
  * Major surgery within 4 weeks prior to study entry
  * Radiation therapy within 4 weeks prior to study entry.
  * Clinically important hypertension
  * Known or suspected hypersensitivity to PF-07220060, PF-07104091, letrozole, fulvestrant, or goserelin (or equivalent to induce chemical menopause if applicable)
* Known abnormalities in coagulation. Anticoagulation with subcutaneous heparin or prophylactic doses of anticoagulant are allowed
* Known active uncontrolled or symptomatic central nervous system (CNS) metastases
* Active inflammatory GI disease
* Current use or anticipated need for Proton Pump Inhibitors (PPI) within 14 days prior to first dose of the study intervention
* Previous high-dose chemotherapy requiring stem cell rescue
* Participants with active, uncontrolled bacterial, fungal, or viral infection, including hepatitis B virus (HBV), hepatitis C virus (HCV), and known human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS) related illness
* Other protocol specific exclusion criteria may apply

• Los Angeles, California, United States
• Los Angeles, California, United States
• Los Angeles, California, United States
• Santa Monica, California, United States
• Santa Monica, California, United States
• Boston, Massachusetts, United States
• Grand Rapids, Michigan, United States
• Kansas City, Missouri, United States
• Dallas, Texas, United States
• Houston, Texas, United States
• Seattle, Washington, United States
• Seattle, Washington, United States
• Viedma, Río Negro Province, Argentina
• Buenos Aires, Argentina
• Córdoba, Argentina
• La Rioja, Argentina
• Ijuí, Rio Grande do Sul, Brazil
• Porto Alegre, Rio Grande do Sul, Brazil
• Porto Alegre, Rio Grande do Sul, Brazil
• Barretos, São Paulo, Brazil
• São Paulo, Brazil
• Sofia, Sofia (stolitsa), Bulgaria
• Haskovo, Bulgaria
• Plovdiv, Bulgaria
• Sofia, Bulgaria
• Vratsa, Bulgaria
• Changchun, Jilin, China
• Shanghai, Shanghai Municipality, China
• Chengdu, Sichuan, China
• Chengdu, Sichuan, China
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