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Cardiac Impairments Following Pediatric Cardiotoxic Anti-cancer Treatment

CompletedN/A

Sponsor: Technical University of Munich

Conditions: Cardiovascular Diseases, Pediatric Cancer

Interventions: Exercise stress echocardiography

Countries: Germany

This study aims at investigating the feasibility of recruitment and application of a method regarding early detection of subclinical changes in cardiac health after completion of acute cancer treatment during childhood and adolescence.

Eligibility overview

Sex: ALL

Age: 10 Years to 25 Years

Healthy volunteers: Yes

Study type: OBSERVATIONAL

Eligibility criteria

Inclusion criteria for all participants:

* Aged between 10 and 25 years
* Body height of ≥1,40m (required for performing the examination on the semi supine bicycle ergometer)
* Signed informed assent (minor participant) and consent (legal guardian and full-aged participant)

Additional inclusion criteria for participants following cancer treatment:

* Completion of acute cancer treatment with anthracyclines and/or chest radiation
* End of treatment 12 months and five years ago (± three months)
* Medical approval for study participation

Additional inclusion criteria for healthy control subjects:

\- Appropriate as matched pair with respect to age and gender

Exclusion Criteria:

* Known cardiovascular diseases (incoherent with cardiotoxic treatment)
* Inability to follow study instructions (e.g., mental retardation, language)
* Acute orthopedic injury (e.g., bone fracture) or orthopedic impairments that preclude examination on a bicycle ergometer (e.g., instable prosthetic device)

All participants receive a basic physical and cardiological examination at rest as part of the study protocol to ensure capability before performing the exercise stress echocardiography.

Locations (1)

Munich, Germany