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Sex Disparities in Hypoxic Vasodilation and Impact of Obesity

NCT05219799

RecruitingEARLY_Phase 1

Sponsor: University of Missouri-Columbia

Conditions: Obesity, Vasodilation, Healthy

Interventions: Propranolol Hydrochloride, Isoproterenol, Phentolamine Mesylate, Norepinephrine

Countries: United States

The purpose of this project is to examine key mechanisms contributing to sex-differences in hypoxic vasodilation and the impact of obesity, with particular emphasis on the sympathetic nervous system.

Eligibility overview

Sex: ALL

Age: 18 Years to 45 Years

Healthy volunteers: Yes

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* BMI \>18 kg/m2

Exclusion Criteria:

* Pregnancy, breastfeeding
* Diagnosed sleep apnea or AHI \>10 events/hr
* Current smoking/Nicotine use
* Increased risk of bleeding, pro-coagulant disorders, clotting disorders, anticoagulation therapy
* Nerve/neurologic disease
* Cardiovascular, hepatic, renal, respiratory disease
* Blood pressure ≥140/90 mmHg
* Diabetes, Polycystic ovarian syndrome
* Communication barriers
* Prescription medications, Sensitivity to lidocaine

Locations (1)

Columbia, Missouri, United States