NCT lookup
Pull any trial record directly from ClinicalTrials.gov.
Sponsor: University of Tennessee Medical Center
Conditions: Alzheimer Disease
Interventions: GammaSense Stimulation device
Countries: United States
The purpose of the study is to investigate the efficacy of cortical gamma oscillation on visual sensory processing and cognitive function in Alzheimer's Disease (AD) patients by combining a therapeutic sensory stimulation device capable of evoking 40-Hz gamma oscillation via non-invasive visual and auditory stimulation with pre-established markers of cortical network activity, i.e., electroencephalography (EEG) and event-related potentials (ERP), to evaluate the applicability of the 40-Hz multimodel sensory stimulation as a novel therapeutic approach for treatment of AD patients.
Sex: ALL
Age: 60 Years to —
Healthy volunteers: No
Study type: INTERVENTIONAL
Inclusion Criteria: * Individuals ages 60 and older with established diagnosis of Alzheimer's Disease as defined by the current consensus criteria for AD (Albert et al, 2011, Jack et al, 2011; McKhann et al, 2011) * Fluent and literate in English language * Able to consent for themselves based upon the MacArthur Competence Assessment Tool for Clinical Research * Patients with a pre-existing positive A(beta)-PET and/or CSF tau/A(beta) markers or willingness to undergo a Lumbar Puncture (LP) with these results Exclusion Criteria: * Not fluent and literate in English * Severe dementia * Other medical conditions/neurodegenerative disease that could significantly impair cognitive abilities * Cardiac pacemakers or any other implants that may not be compatible with MRI * Cognitively impaired to the point the patient is unable to consent for themselves * Claustrophobic to the point that medication is required
- Knoxville, Tennessee, United States