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Imaging the Interplay Between Axonal Damage and Repair in Multiple Sclerosis

RecruitingN/A

Sponsor: University Hospital, Basel, Switzerland

Conditions: Multiple Sclerosis (MS), Relapsing-remitting Multiple Sclerosis (RRMS), Secondary-progressive Multiple Sclerosis (SPMS), Primary Progressive Multiple Sclerosis (PPMS)

Interventions: MRI, Neurocognitive examination for healthy subjects, blood sampling

Countries: Switzerland

This project is to: 1. Quantify differences in axonal integrity and organization in aMS versus naPMS patients. 2. Quantify changes in axonal integrity and organization in aMS versus naPMS patients over a two-year period. 3. Validate the combination of imaging parameters that best differentiate aMS versus naPMS patients using histopathology.

Eligibility overview

Sex: ALL

Age: 18 Years to 80 Years

Healthy volunteers: Yes

Study type: OBSERVATIONAL

Eligibility criteria

Inclusion Criteria for patients:

* Patients may be diagnosed with:

  1. active RRMS (n=100): Relapsing-remitting course and \> 1 clinical relapse and/or signs of MRI activity (\> 1 Gd enhancing lesion) during the last year before study enrollment.
  2. non-active PMS (n=100): Progressive course (PPMS or SPMS) and no clinical relapses and/or signs of MRI activity during the last year before study enrollment.
* Age 18-80 years old
* No other neurological or psychiatric disorder

Inclusion criteria for healthy controls:

* Age 18-80 years old
* No other neurological or psychiatric disorder

Exclusion Criteria for patients and healthy controls:

* Pregnancy
* Contraindication to MRI (eg, claustrophobia, metallic implants, pacemaker etc).
* Inability to give consent

Locations (1)

Basel, Switzerland