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Registry of Patients with Suspected Amyloidosis in Heart Failure

Active Not RecruitingN/A

Sponsor: Fundación Pública Andaluza para la gestión de la Investigación en Sevilla

Conditions: Heart Failure

Interventions: Bone-cardiac scintigraphy

Countries: Spain

Observational multicenter registry of cohorts with follow-up. Patients with heart failure, age ≥ 18 years, with clinical suspicion of cardiac amyloidosis and any LVEF value, treated in the field of Internal Medicine. Initially, a duration of two years was established to recruit at least 150 patients in the group with AC, and a follow-up of two years. Upon completion of the two years of follow-up, the continuity or completion of the registry will be assessed.

Eligibility overview

Sex: ALL

Age: 18 Years to —

Healthy volunteers: No

Study type: OBSERVATIONAL

Eligibility criteria

INCLUSION CRITERIA:

* Age ≥ 18 years.
* Both genders.
* Heart Failure (2021 European Society of Cardiology criteria)
* Any LVEF value.
* Outpatients or hospitalized patients in Internal Medicine Units
* Patients with suspicion criteria proposed by the European Society of Cardiology:

  * Ventricular hypertrophy ≥ 12 mm

And one or more of the following criteria:

* Heart failure in ≥ 65 years
* Aortic stenosis in ≥ 65 years
* Hypotension or Normotensive if previously hypertensive
* Sensory involvement, autonomic dysfunction
* Peripheral polyneuropathy
* Proteinuria
* Skin bruising (eg, periorbital purpura)
* Bilateral carpal tunnel syndrome
* Ruptured biceps tendon
* In CMR: Subendocardial / transmural late gadolinium enhancement (LGE), or increased extracellular volume (ECV)
* In ECO: Reduced longitudinal strain with apical sparing
* Reduced QRS voltage to mass ratio
* Pseudo Q waves on ECG
* Atrioventricular conduction disease
* Possible family history of ATTRv

EXCLUSION CRITERIA:

* Refusal to participate in the registry

Locations (1)

Seville, SEVILLA, Spain