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Inclusion Criteria:

* Advanced chronic Heart Failure with Reduced Ejection Fraction (HFrEF), defined as left ventricular ejection fraction (LVEF) less than or equal to (≤) 35% at Screening, including documented history of HFrEF (LVEF ≤ 35%) for at least 4 months prior to Screening
* New York Heart Association Class II-IV
* Cardiac index ≤ 2.5 liters per minute per square meter (L/min/m\^2) and pulmonary capillary wedge pressure ≥ 15 millimeters of mercury (mm Hg) at Day 1
* Body mass index 18.0 to 37.0 kilograms per square meter (kg/m\^2), inclusive, and body weight \< 150 kg at Screening and Day 1

Exclusion Criteria:

* Hemodynamically unstable at Day 1 or in the opinion of the Investigator likely to progress to becoming hemodynamically unstable during the course of the study
* Treated with carvedilol or at a dose higher than a total of 25 milligrams per day any time within 72 hours of Day 1 through the end of the in-clinic observation Post-dose Period.
* Receiving any mechanical (respiratory or circulatory) or renal support therapy at Screening or Day 1
* Systolic Blood Pressure ≤ 90 millimeter of mercury (mm Hg) or ≥ 160 mm Hg, or Heart Rate \< 50 beats per minute (bpm) or \> 110 bpm, at Screening or Day 1
* Recently treated with inotropic, intravenous (IV) vasoactive or IV diuretic therapy, or expected to require such therapy with these drugs any time from Day 1 through the end of study conduct.

• Tampa, Florida, United States
• Peoria, Illinois, United States
• Houston, Texas, United States
• Salt Lake City, Utah, United States
• Madison, Wisconsin, United States
• Bernau bei Berlin, Brandenburg, Germany
• Bad Nauheim, Germany
• Greifswald, Germany
• Nea Ionia, Athens, Greece
• Pylaia, Thessaloniki, Greece
• Larissa, Greece
• Gniezno, Poland
• Krakow, Poland
• Wroclaw, Poland
• Belgrade, Serbia
• Belgrade, Serbia
• Belgrade, Serbia
• Belgrade, Serbia
• Kamenitz, Serbia
• Kragujevac, Serbia
• Užice, Serbia