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A Study to Evaluate White Matter Hyperintensities in Migraine

NCT05112289

Active Not RecruitingNA

Sponsor: Mayo Clinic

Conditions: Migraine, Small Vessel Ischemic Disease, Multiple Sclerosis

Interventions: Brain Neuroimaging

Countries: United States

The purpose of this research is to better understand brain white matter hyperintensities (WMH) in women with migraines

Eligibility overview

Sex: FEMALE

Age: 20 Years to 59 Years

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria - Migraine (N=20):

* Female only.
* Ages 20-45 years.
* Presence of WMH on MRI.

Exclusion Criteria:

* History of SVI and/or history of MS or other neurological disease other than migraine.
* History of cancer or organ transplantation.
* Contraindication to MRI.
* Pregnancy.
* History of abnormal brain MRI other than WMH.
* Subjects not willing to comply with the study procedures will be removed from the study.

Inclusion Criteria - SVI disease (n=10):

* Female only
* Ages \> 60 years.
* Presence of WMH on MRI.

Exclusion Criteria:

* History of migraine and/or history of MS or other neurological disease other than SVI.
* History of cancer or organ transplantation.
* History of abnormal brain MRI other than WMH.
* Pregnancy.
* History of abnormal brain MRI other than WMH.
* Subjects not willing to comply with the study procedures will be removed from the study.

Inclusion Criteria - MS (n=10):

* Female only.
* Ages 20-45.
* Presence of WMH on MRI.

Exclusion Criteria:

* History of migraine and/or history of SVI or other neurological disease other than MS.
* History of cancer or organ transplantation.
* History of abnormal brain MRI other than WMH.
* Pregnancy.
* History of abnormal brain MRI other than WMH.
* Subjects not willing to comply with the study procedures will be removed from the study.

Locations (1)

Phoenix, Arizona, United States