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A Study of LY3372689 to Assess the Safety, Tolerability, and Efficacy in Participants With Alzheimer's Disease
A Study of LY3372689 to Assess the Safety, Tolerability, and Efficacy in Participants With Alzheimer's Disease

NCT05063539

CompletedPhase 2

Sponsor: Eli Lilly and Company

Conditions: Alzheimer Disease

Interventions: LY3372689, LY3372689, Placebo

Countries: United States, Australia, Canada, Japan, Poland

The purpose of this study is to assess the safety, tolerability and effect of study drug LY3372689 in participants with early symptomatic Alzheimer's Disease

Eligibility overview

Sex: ALL

Age: 60 Years to 85 Years

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria
Inclusion Criteria:

* Gradual and progressive change in memory function reported by participants or informants for ≥ 6 months
* MMSE score of 22 to 30 (inclusive) at screening
* CDR global score of 0.5 to 1.0 (inclusive), with a memory box score ≥0.5.
* Meet 18F flortaucipir positron emission tomography (PET) scan (central analysis) criteria
* Have a study partner who will provide written informed consent to participate

Exclusion Criteria:

* Contraindication to MRI or PET scans
* Have known allergies to LY3372689, related compounds, or any components of the formulations
Locations (69)
  • Canoga Park, California, United States
  • Fresno, California, United States
  • Irvine, California, United States
  • San Diego, California, United States
  • New Haven, Connecticut, United States
  • Atlantis, Florida, United States
  • Aventura, Florida, United States
  • Boca Raton, Florida, United States
  • Delray Beach, Florida, United States
  • Fort Myers, Florida, United States
  • Maitland, Florida, United States
  • Melbourne, Florida, United States
  • Merritt Island, Florida, United States
  • Miami, Florida, United States
  • Miami, Florida, United States
  • Miami, Florida, United States
  • New Port Richey, Florida, United States
  • Ocala, Florida, United States
  • Pembroke Pines, Florida, United States
  • Stuart, Florida, United States
  • The Villages, Florida, United States
  • Indianapolis, Indiana, United States
  • Newton, Massachusetts, United States
  • Plymouth, Massachusetts, United States
  • Waltham, Massachusetts, United States
  • Watertown, Massachusetts, United States
  • Springfield, New Jersey, United States
  • Toms River, New Jersey, United States
  • Buffalo, New York, United States
  • Abington, Pennsylvania, United States
  • + 39 more on CT.gov