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Continued Access Study for Participants Deriving Benefit in Pfizer-Sponsored Avelumab Parent Studies That Are Closing
Continued Access Study for Participants Deriving Benefit in Pfizer-Sponsored Avelumab Parent Studies That Are Closing

NCT05059522

Active Not RecruitingPhase 3

Sponsor: Pfizer

Conditions: Advanced Malignancies, NSCLC, Ovarian Cancer, Urothelial Cancer, Solid Tumors

Interventions: Avelumab, Lorlatanib, Talazoparib, Pemetrexed, Axitinib

Countries: United States, Australia, Belgium, Canada, Denmark, France, Hungary, Israel

This Master Protocol for Avelumab Continuation Sub-Studies is to provide continued treatment access, safety follow-up, and when applicable, overall survival follow-up for eligible participants who continue to derive a benefit from study intervention in the Pfizer-sponsored Avelumab parent studies.

Eligibility overview

Sex: ALL

Age: 18 Years to —

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria
Inclusion Criteria:

1. Any participant who is receiving study treatment and deriving significant clinical benefit or is in the safety and/or survival follow-up period in a Pfizer-sponsored Avelumab Parent Study.
2. Participants must agree to follow the reproductive criteria.
3. Participants must be willing and able to comply with all scheduled visits, treatment plan, and other study procedures.

Exclusion Criteria:

1. Female participants who are pregnant or breastfeeding.
2. Any medical reason that, in the opinion of the Investigator or Sponsor, precludes the participant from inclusion in the study.
Locations (71)
  • Fayetteville, Arkansas, United States
  • Rogers, Arkansas, United States
  • Springdale, Arkansas, United States
  • Los Angeles, California, United States
  • Los Angeles, California, United States
  • Tampa, Florida, United States
  • Basking Ridge, New Jersey, United States
  • Middletown, New Jersey, United States
  • Montvale, New Jersey, United States
  • Commack, New York, United States
  • Harrison, New York, United States
  • Long Island City, New York, United States
  • New York, New York, United States
  • New York, New York, United States
  • New York, New York, United States
  • Uniondale, New York, United States
  • Philadelphia, Pennsylvania, United States
  • Philadelphia, Pennsylvania, United States
  • Houston, Texas, United States
  • Seattle, Washington, United States
  • North Ryde, New South Wales, Australia
  • Wollstonecraft, New South Wales, Australia
  • Wollstonecraft, New South Wales, Australia
  • Chermside, Queensland, Australia
  • Ghent, Oost-vlaanderen, Belgium
  • Gilly, Belgium
  • Edmonton, Alberta, Canada
  • Kingston, Ontario, Canada
  • Aalborg, North Denmark, Denmark
  • Vandœuvre-lès-Nancy, Lorraine, France
  • + 41 more on CT.gov