NCT lookup
Pull any trial record directly from ClinicalTrials.gov.
Sponsor: University of Jordan
Conditions: Multiple Sclerosis
Interventions: Sleep quality and physical activity, Nicotine dependence, Nicotine and cotinine serum levels, Smoking
Countries: Jordan
Current evidence suggests that cigarette smoke increases disease progression in people with multiple sclerosis (PwMS) and worsen their symptoms. 70% of PwMS report sleep disturbances that negatively affects their quality of life. Cigarette smoke has been found to be associated with sleep disturbances in healthy adult smokers, but this relationship is unknown in PwMS. Also, those who smoke cigarettes have less physical endurance resulting in undesirable effects on physical activity. Also, current evidence suggests that genes play a major role in smoking behavior and that certain genetic differences greatly affects nicotine dependence. To our knowledge, this was never explored before among PwMS. This study aims to explore the association between cigarette smoke, sleep quality, and physical activity in PwMS. Another aim is to explore the genetic susceptibility of people with MS to cigarette smoke, specifically to nicotine dependence
Sex: ALL
Age: 18 Years to —
Healthy volunteers: No
Study type: OBSERVATIONAL
Inclusion Criteria 1. Confirmed diagnosis of MS from a neurologist using the McDonald diagnostic criteria 2. Ability to ambulate independently with or without an assistive device 3. Current, previous, and nonsmokers 4. Age ≥ 18 years 5. Ability to give informed consent. Exclusion Criteria 1. A neurological disease other than MS 2. Orthopedic problems or other conditions that may significantly interfere with testing 3. Uncorrected vision loss 4. Acute ischemic cardiovascular event or coronary artery bypass surgery less than 3 months ago 5. Uncontrolled blood pressure with medication (BP\>190/110mmHg).
- Amman, Jordan