NCT lookup

Pull any trial record directly from ClinicalTrials.gov.

Late Onset Alzheimer's Disease

RecruitingN/A

Sponsor: Columbia University

Conditions: Alzheimer Disease

Interventions: Blood Draw, Late Onset Alzheimer's Disease (LOAD) Neuropsychological Battery Test

Countries: United States

The goal of this study is to is to focus on the genetic influences on Alzheimer's Disease (AD) risk. The investigators are looking for families and/or individuals (affected or unaffected) of any ethic background (African American, Caucasian, and Hispanics) with a family history of AD and willing to participate.

Eligibility overview

Sex: ALL

Age: 55 Years to —

Healthy volunteers: Yes

Study type: OBSERVATIONAL

Eligibility criteria

Inclusion Criteria:

* Established diagnosis of definite or probable AD or have a diagnosis of a related neurodegenerative disorder such as Frontotemporal Dementia (FTD) or Lewy Body Dementia (LBD) (will also recruit sporadic FTD and LBD) cases.
* a living sibling with probable or possible AD;
* a third living relative affected with AD (onset age 50 or older) or unaffected (60 or older);
* participants in the proband's generation with an identified companion serving as an informant;
* participants who have capacity to consent or participants lacking capacity to consent with a surrogate/proxy in place to provide consent.

Exclusion Criteria:

* failure to identify an appropriate informant;
* uncertainty of the clinical diagnosis of Alzheimer's disease or other related disorder;
* discovery of additional diagnosis that could account for the clinical manifestations;
* unwillingness to participate;
* failure to identify a living sibling with AD or other related disorder (except in the cases of sporadic FTD and sporadic LBD);
* participants lacking the capacity to consent who do not have a surrogate or proxy or next of kin to provide consent.

Locations (12)

Washington D.C., District of Columbia, United States
Miami, Florida, United States
Aurora, Illinois, United States
Bloomington, Indiana, United States
Indianapolis, Indiana, United States
Rochester, Minnesota, United States
St Louis, Missouri, United States
New York, New York, United States
Raleigh, North Carolina, United States
Pittsburgh, Pennsylvania, United States
Dallas, Texas, United States
Seattle, Washington, United States