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The Therapeutic Effects of Forced Aerobic Exercise in Multiple Sclerosis

CompletedNA

Sponsor: The Cleveland Clinic

Conditions: Multiple Sclerosis

Interventions: Forced Aerobic Exercise (FE), Voluntary Aerobic Exercise (VE)

Countries: United States

This project will investigate the feasibility and initial efficacy of two aerobic exercise training approaches, forced and voluntary, to improve motor function in persons with multiple sclerosis (MS). We hypothesize that intensive aerobic exercise training elicits a neurorepairative and neurorestorative response on the central nervous system, which may improve motor function as it relates to gait and mobility. Should aerobic cycling, forced or voluntary, improve gait and functional mobility in persons with MS, it would serve as a new model to restoring function, rather than current models that focus on compensation.

Eligibility overview

Sex: ALL

Age: 18 Years to 75 Years

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

1. Confirmed diagnosis of RRMS with Expanded Disability Status Scale (EDSS) score between 1.5 and 6.5,
2. 18-75 years of age,
3. Deemed minimal risk for cardiovascular event using American College of Sports Medicine Exercise Pre-participation Criteria

Exclusion Criteria:

1. hospitalization for myocardial infarction, heart failure or heart surgery within 3 months,
2. serious cardiac arrhythmia,
3. hypertrophic cardiomyopathy,
4. severe aortic stenosis,
5. pulmonary embolus,
6. significant contractures,
7. dysphagia resulting in inability to sufficiently hydrate, and
8. other contraindication to exercise.

Locations (2)

Cleveland, Ohio, United States
Cleveland, Ohio, United States